Endocardium development

Across TCGA patient cohorts, RNA activity of the Endocardium development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP2, GMIP, and APOBR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardium development activity versus GBP2 in HNSC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GBP2 →	-0.437	-0.063	<.001	.001	3	6
UCEC	GMIP →	-0.254	-0.077	<.001	<.001	3	6
UCEC	APOBR →	-0.436	-0.068	.001	.002	3	6
CCRCC	PTK2 →	+0.220	+0.070	<.001	<.001	3	6
LSCC	RAC2 →	-0.474	-0.060	<.001	<.001	3	6
HNSC	PSTPIP1 →	-0.409	-0.074	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003157 vs GBP2 — HNSC

Explore this scatter interactively →