Endocardium development

Across TCGA cell cohorts, RNA activity of the Endocardium development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAF1, RAB11B, and FAM135A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endocardium development activity versus NDUFAF1 in BONE (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NDUFAF1 →	-0.759	-0.870	.004	.007	3	5
OESOPHAGUS	RAB11B →	+1.220	+0.257	.005	.005	3	4
SKIN	FAM135A →	+0.793	+0.384	.003	.006	3	3
OESOPHAGUS	NRAS →	-1.470	-0.257	.007	.005	3	3
BLOOD_Leukemia	H4C1 →	+1.368	+0.371	.001	<.001	3	3
OVARY	SLC16A8 →	+1.427	+0.296	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003157 vs NDUFAF1 — BONE

Explore this scatter interactively →