Regulation of animal organ formation

Across TCGA patient cohorts, RNA activity of the Regulation of animal organ formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CCDC102A_S537, SEPTIN2, and STK38L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of animal organ formation activity versus CCDC102A_S537 in OV (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCDC102A_S537 →	+1.178	+0.088	.002	.002	3	5
GBM	SEPTIN2 →	+0.212	+0.092	.001	<.001	3	5
LUAD	STK38L →	+0.167	+0.049	<.001	<.001	3	5
GBM	CAPN2 →	+0.481	+0.085	<.001	<.001	3	5
BRCA	ANXA2_S161 →	+0.678	+0.049	<.001	.001	3	5
BRCA	MEGF6 →	+0.497	+0.036	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003156 vs CCDC102A_S537 — OV

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