Regulation of animal organ formation

Across TCGA patient cohorts, RNA activity of the Regulation of animal organ formation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF1, DACT3, and NEIL3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of animal organ formation activity versus FGF1 in CCRCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FGF1 →	+0.676	+0.523	.004	.004	2	6
BRCA	DACT3 →	+0.562	+0.558	.005	.004	3	5
BRCA	NEIL3 →	-0.849	-0.733	<.001	<.001	3	4
BRCA	CEP55 →	-0.734	-0.559	.003	<.001	3	4
UCEC	BUB1 →	-0.951	-0.631	.001	.001	3	4
UCEC	SLC25A15P5 →	+0.864	+0.566	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003156 vs FGF1 — CCRCC

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