Regulation of animal organ formation

Across TCGA cell cohorts, RNA activity of the Regulation of animal organ formation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RABGGTB, EPSTI1, and PSME1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RABGGTB grouped by Regulation of animal organ formation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RABGGTB →	+0.649	+0.758	.002	.005	3	4
CNS	EPSTI1 →	-1.660	-1.032	.002	.001	3	4
CNS	PSME1 →	-0.572	-0.776	<.001	.001	3	4
SOFT_TISSUE	APH1B →	+1.347	+1.310	<.001	<.001	3	4
STOMACH	EIF4E →	+0.729	+1.342	.004	<.001	3	4
SKIN	TIAM2 →	-0.614	-0.678	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RABGGTB by Regulation of animal organ formation activity — LARGE_INTESTINE

Explore this box plot interactively →