Regulation of animal organ formation

Across TCGA cell cohorts, RNA activity of the Regulation of animal organ formation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP1-AS1, PLEKHG1, and DHX57, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLGAP1-AS1 grouped by Regulation of animal organ formation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DLGAP1-AS1 →	+0.121	+0.152	.003	.009	3	4
KIDNEY	PLEKHG1 →	-0.198	-0.184	<.001	<.001	3	4
KIDNEY	DHX57 →	+0.323	+0.181	.002	.001	3	4
KIDNEY	ZNF556 →	+0.211	+0.153	.001	.007	3	4
SKIN	OR1S2 →	+0.224	+0.172	.001	.006	3	4
LUNG_NSCLC_LUSC	ICAM2 →	-0.336	-0.248	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLGAP1-AS1 by Regulation of animal organ formation activity — SKIN

Explore this box plot interactively →