Outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Outflow tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNS2, TNS2_S120, and HSPB6, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract morphogenesis activity versus TNS2 in CCRCC (Pearson r = 0.73).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNS2 →	+0.510	+0.084	<.001	<.001	3	10
LUAD	TNS2_S120 →	+0.616	+0.052	<.001	<.001	3	10
BRCA	HSPB6 →	+1.178	+0.045	<.001	<.001	3	10
PDAC	LMCD1_S16 →	+0.647	+0.032	.001	<.001	3	10
OV	TNS2_S102 →	+0.954	+0.044	<.001	<.001	3	10
CCRCC	ARHGEF17 →	+0.490	+0.085	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003151 vs TNS2 — CCRCC

Explore this scatter interactively →