Outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AXIN2, GAB1, and GRM6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract morphogenesis activity versus AXIN2 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AXIN2 →	+0.819	+0.610	<.001	<.001	3	5
BRCA	GAB1 →	+0.392	+0.453	.006	<.001	3	5
PDAC	GRM6 →	+0.179	+0.445	<.001	.001	3	5
BRCA	CEP68 →	+0.318	+0.387	.001	.003	3	5
HNSC	ZNF493 →	+0.662	+0.623	.003	<.001	3	5
HNSC	ZNF345 →	+0.519	+0.430	<.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003151 vs AXIN2 — BRCA

Explore this scatter interactively →