Outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Outflow tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOVA2, KIF7_S895, and RGS19_S214, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract morphogenesis activity versus NOVA2 in PDAC (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	NOVA2 →	+0.474	+0.373	<.001	.001	3	4
OV	KIF7_S895 →	+1.064	+1.032	.001	.002	3	4
GBM	RGS19_S214 →	-0.492	-0.674	<.001	.001	3	3
UCEC	SP4_S46 →	+0.581	+0.737	.002	<.001	3	3
CCRCC	SQSTM1_S152 →	-1.838	-0.993	<.001	<.001	3	3
OV	ZC2HC1A_S279 →	+1.731	+1.428	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003151 vs NOVA2 — PDAC

Explore this scatter interactively →