Outflow tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM165, MARCHF3, and RHBDD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM165 grouped by Outflow tract morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM165 →	-1.023	-0.208	<.001	<.001	3	5
BLOOD_Leukemia	MARCHF3 →	-1.613	-0.924	.001	.007	3	4
KIDNEY	RHBDD3 →	+0.567	+1.066	.002	.004	3	4
LUNG_NSCLC_LUSC	NRP1 →	-3.263	-0.270	.002	.009	3	4
OESOPHAGUS	PPP2R2D →	+0.966	+0.272	<.001	<.001	3	4
SKIN	FNDC3B →	-0.538	-0.383	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM165 by Outflow tract morphogenesis activity — BREAST

Explore this box plot interactively →