Outflow tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBR2, NRP1, and ITGB1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract morphogenesis activity versus TGFBR2 in BONE (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TGFBR2 →	+2.136	+0.110	.004	.004	3	12
LUNG_NSCLC_LUSC	NRP1 →	+2.815	+0.088	<.001	.001	3	9
BONE	ITGB1 →	+1.559	+0.134	.005	<.001	3	9
BONE	TGFB2 →	+3.310	+0.147	<.001	<.001	3	9
BONE	LMCD1 →	+2.379	+0.146	.007	<.001	3	9
BONE	ACTN4 →	+1.323	+0.084	.006	.006	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003151 vs TGFBR2 — BONE

Explore this scatter interactively →