Membranous septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Membranous septum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TGFB2, TIMP2, and FKBP7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membranous septum morphogenesis activity versus TGFB2 in UCEC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TGFB2 →	+0.843	+0.096	<.001	<.001	3	7
OV	TIMP2 →	+0.709	+0.108	<.001	<.001	3	7
OV	FKBP7 →	+0.506	+0.071	<.001	<.001	3	7
BRCA	FZD1 →	+0.681	+0.074	<.001	<.001	3	7
OV	ISLR →	+0.909	+0.102	<.001	<.001	3	7
OV	CSRP2 →	+0.725	+0.082	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003149 vs TGFB2 — UCEC

Explore this scatter interactively →