Membranous septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Membranous septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C4orf46, CPSF3, and DESI2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membranous septum morphogenesis activity versus C4orf46 in UCEC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4orf46 →	+0.542	+0.393	<.001	.003	3	7
UCEC	CPSF3 →	+0.717	+0.569	<.001	.008	3	5
BRCA	DESI2 →	+0.642	+0.561	<.001	<.001	3	5
LSCC	STIL →	+0.940	+0.282	<.001	<.001	3	5
LSCC	DEK →	+0.879	+0.311	<.001	<.001	3	5
UCEC	AUNIP →	+0.826	+0.441	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003149 vs C4orf46 — UCEC

Explore this scatter interactively →