Membranous septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Membranous septum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TACC3, TALDO1_S237, and UBE2S, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membranous septum morphogenesis activity versus TACC3 in UCEC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TACC3 →	+0.595	+0.555	<.001	<.001	3	4
OV	TALDO1_S237 →	-0.623	-0.616	<.001	<.001	3	4
UCEC	UBE2S →	+0.559	+0.728	<.001	.001	3	4
UCEC	CENPF →	+0.565	+0.527	<.001	<.001	3	4
UCEC	CENPF_S3079 →	+0.832	+0.440	<.001	<.001	3	4
LSCC	NSD2 →	+0.787	+0.447	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003149 vs TACC3 — UCEC

Explore this scatter interactively →