Membranous septum morphogenesis

Across TCGA cell cohorts, RNA activity of the Membranous septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB17, GPX3, and PLEKHF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB17 grouped by Membranous septum morphogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RAB17 →	-3.423	-1.518	<.001	<.001	3	4
LIVER	GPX3 →	-4.335	-1.358	.001	.003	3	4
PANCREAS	PLEKHF1 →	+1.194	+1.300	.001	.001	3	4
KIDNEY	CTSL →	+1.231	+1.049	.003	.004	3	4
LARGE_INTESTINE	ANKRD13B →	+0.782	+0.872	.002	.001	3	4
LIVER	TRIM7 →	+2.890	+1.479	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB17 by Membranous septum morphogenesis activity — LIVER

Explore this box plot interactively →