Outflow tract septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Outflow tract septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN21, RBFOX2, and PRICKLE2, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract septum morphogenesis activity versus PTPN21 in THYM (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	PTPN21 →	+1.751	+0.092	<.001	<.001	3	29
THYM	RBFOX2 →	+1.292	+0.074	<.001	<.001	3	28
THYM	PRICKLE2 →	+1.662	+0.092	<.001	<.001	3	28
THYM	NRP2 →	+2.359	+0.097	<.001	<.001	3	28
THYM	EDNRA →	+2.432	+0.090	<.001	<.001	3	28
THYM	JAM3 →	+1.582	+0.084	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003148 vs PTPN21 — THYM

Explore this scatter interactively →