Outflow tract septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Outflow tract septum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFEMP1, NCL_S67, and FKBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outflow tract septum morphogenesis activity versus EFEMP1 in LSCC (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EFEMP1 →	+0.641	+0.087	<.001	<.001	3	8
BRCA	NCL_S67 →	-0.927	-0.044	<.001	<.001	3	8
LSCC	FKBP7 →	+0.677	+0.078	<.001	<.001	3	8
CCRCC	SORBS3 →	+0.351	+0.040	<.001	<.001	3	8
UCEC	HSPA12A →	+0.601	+0.084	<.001	.002	3	8
BRCA	HTRA1 →	+0.887	+0.041	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003148 vs EFEMP1 — LSCC

Explore this scatter interactively →