Outflow tract septum morphogenesis

Across TCGA cell cohorts, RNA activity of the Outflow tract septum morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D16, PRKCZ, and NCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D16 grouped by Outflow tract septum morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D16 →	-0.152	-0.092	<.001	<.001	3	5
LUNG_NSCLC_LUSC	PRKCZ →	-0.198	-0.133	.004	.004	3	5
LUNG_SCLC	NCR2 →	-0.232	-0.119	.004	.007	3	4
LARGE_INTESTINE	KRT4 →	-0.153	-0.138	.006	.001	3	4
LUNG_SCLC	EEF1AKMT1 →	-0.261	-0.160	.007	<.001	3	4
BREAST	KDM1A →	-0.353	-0.103	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D16 by Outflow tract septum morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →