Embryonic heart tube morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic heart tube morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BHLHE41, RPL24, and GPR150, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BHLHE41 grouped by Embryonic heart tube morphogenesis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BHLHE41 →	-2.000	-0.172	.001	.006	2	5
STOMACH	RPL24 →	+0.501	+0.716	.002	.007	3	4
BLOOD_Leukemia	GPR150 →	-0.655	-1.104	.004	.001	3	4
BLOOD_Leukemia	ALKBH2 →	+0.717	+1.219	.002	<.001	3	4
BONE	ARSL →	-2.078	-1.281	<.001	<.001	3	4
BONE	ZNF219 →	+1.725	+1.279	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BHLHE41 by Embryonic heart tube morphogenesis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →