Embryonic heart tube morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic heart tube morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TEAD2, KIF2C, and FOSL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic heart tube morphogenesis activity versus TEAD2 in KIDNEY (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TEAD2 →	-3.067	-0.877	.002	.007	3	6
BREAST	KIF2C →	-1.028	-0.997	.001	.005	2	6
OVARY	FOSL1 →	-3.143	-0.422	.001	.001	3	4
BREAST	FST →	-1.927	-0.846	<.001	.002	3	4
BREAST	CEP57L1 →	-0.953	-0.963	.001	.003	3	4
BREAST	ZNF559 →	-1.229	-0.857	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003143 vs TEAD2 — KIDNEY

Explore this scatter interactively →