Determination of left/right asymmetry in lateral mesoderm

Across TCGA patient cohorts, RNA activity of the Determination of left/right asymmetry in lateral mesoderm pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2L6, FSTL1, and IFIT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of left/right asymmetry in lateral mesoderm activity versus UBE2L6 in LSCC (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UBE2L6 →	-0.567	-0.129	<.001	<.001	3	5
CCRCC	FSTL1 →	+0.868	+0.089	<.001	<.001	3	5
LSCC	IFIT1 →	-0.702	-0.106	<.001	<.001	3	4
LSCC	ISG15 →	-0.736	-0.094	<.001	<.001	3	4
COAD	PPP6R3 →	-0.144	-0.057	.005	.001	3	4
LSCC	CHST14 →	+0.324	+0.093	.004	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003140 vs UBE2L6 — LSCC

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