Determination of left/right asymmetry in lateral mesoderm

Across TCGA patient cohorts, RNA activity of the Determination of left/right asymmetry in lateral mesoderm pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FAM53C_S299, SDCBP_Y46, and SMO_S771, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Determination of left/right asymmetry in lateral mesoderm activity versus FAM53C_S299 in OV (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM53C_S299 →	-0.935	-0.330	.002	.002	3	3
UCEC	SDCBP_Y46 →	-1.151	-0.728	<.001	<.001	3	3
LSCC	SMO_S771 →	+0.798	+0.570	<.001	<.001	3	3
CCRCC	FBN2 →	+1.375	+0.768	<.001	.001	3	3
LSCC	MTCL1_S622 →	+1.096	+1.126	<.001	<.001	3	3
LUAD	SAA2 →	-1.668	-0.506	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003140 vs FAM53C_S299 — OV

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