Determination of left/right asymmetry in lateral mesoderm

Across TCGA cell cohorts, RNA activity of the Determination of left/right asymmetry in lateral mesoderm pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAP30, NDUFB1, and IFT52, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAP30 grouped by Determination of left/right asymmetry in lateral mesoderm-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SAP30 →	-1.265	-1.502	.001	<.001	3	4
BLOOD_Leukemia	NDUFB1 →	-0.505	-0.794	.002	.003	2	4
LUNG_SCLC	IFT52 →	-0.853	-1.325	.004	.002	3	3
LUNG_SCLC	MAP3K15 →	+1.268	+1.023	.001	.007	2	4
BLOOD_Lymphoma	HPS1 →	-1.036	-2.152	.002	<.001	3	3
PANCREAS	DYNLRB1 →	-0.783	-1.158	.005	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAP30 by Determination of left/right asymmetry in lateral mesoderm activity — PANCREAS

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