Secondary heart field specification

Across TCGA patient cohorts, RNA activity of the Secondary heart field specification pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53INP1, C9orf16, and SLC9A3R1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Secondary heart field specification activity versus TP53INP1 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TP53INP1 →	+0.718	+0.503	<.001	<.001	3	4
LSCC	C9orf16 →	-0.499	-0.477	<.001	.001	3	4
LSCC	SLC9A3R1 →	-0.756	-0.541	.009	.008	2	4
PDAC	IRAK2 →	-0.612	-0.567	<.001	.001	3	3
LSCC	GAS2L1 →	-0.494	-0.513	<.001	.001	3	3
LUAD	FNDC3B →	-0.331	-0.648	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003139 vs TP53INP1 — LSCC

Explore this scatter interactively →