Heart field specification

Across TCGA cell cohorts, RNA activity of the Heart field specification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RELCH, SMAD2, and PIGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RELCH grouped by Heart field specification-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RELCH →	-0.646	-0.848	.003	.004	3	5
OVARY	SMAD2 →	-0.852	-1.028	.001	<.001	3	4
KIDNEY	PIGN →	-0.776	-0.894	<.001	.001	3	4
SKIN	NKAP →	-0.401	-0.679	.003	.004	2	4
SKIN	ALG13 →	-0.572	-0.630	<.001	.008	3	3
KIDNEY	SS18 →	-0.720	-1.155	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RELCH by Heart field specification activity — KIDNEY

Explore this box plot interactively →