Regulation of systemic arterial blood pressure by endothelin

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by endothelin pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FOSL2, AHNAK2_S842, and LGALS1_S30, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by endothelin activity versus FOSL2 in GBM (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FOSL2 →	+0.516	+0.096	.001	<.001	3	5
LUAD	AHNAK2_S842 →	+0.774	+0.092	<.001	<.001	3	4
GBM	LGALS1_S30 →	+0.654	+0.084	.002	.001	3	4
OV	BCLAF1 →	-0.166	-0.063	<.001	.004	3	4
PDAC	SAMD4B_S592 →	+0.454	+0.081	<.001	.001	3	4
CCRCC	SRP72_T571 →	-0.385	-0.089	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003100 vs FOSL2 — GBM

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