Regulation of systemic arterial blood pressure by endothelin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by endothelin pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIP4P1, CARD9, and ANXA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIP4P1 grouped by Regulation of systemic arterial blood pressure by endothelin-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PIP4P1 →	+0.203	+0.284	.008	.007	3	4
BONE	CARD9 →	-0.335	-0.276	.002	.008	3	4
BONE	ANXA4 →	-0.360	-0.366	.002	.002	3	4
LARGE_INTESTINE	LRRTM4 →	-0.161	-0.206	.007	.002	3	3
LARGE_INTESTINE	SPTB →	-0.136	-0.192	<.001	.008	3	3
LARGE_INTESTINE	ERP29 →	+0.187	+0.248	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIP4P1 by Regulation of systemic arterial blood pressure by endothelin activity — CNS

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