Renal water transport

pathway activity — cross-omics
GO:0003097Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Renal water transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MLLT6, RNU6-233P, and CPE, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAMLLT6 →+0.829+0.952<.001<.00135
PDACRNU6-233P →+0.447+0.381<.001.00634
BRCACPE →-0.900-0.734.004.00134
LUADNTAQ1 →+0.551+0.563<.001.00333
LUADRNU6-43P →+0.761+0.615<.001.00133
HNSCTMSB4XP8 →+0.981+0.707.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration