Renal sodium ion transport

Across TCGA patient cohorts, RNA activity of the Renal sodium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA1, RSU1, and RFC3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion transport activity versus ITGA1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ITGA1 →	+0.451	+0.049	.001	<.001	3	9
UCEC	RSU1 →	+0.369	+0.057	.006	.009	3	8
LSCC	RFC3 →	-0.313	-0.091	<.001	<.001	3	8
LSCC	SNRNP200 →	-0.208	-0.067	<.001	<.001	3	8
LSCC	PRPF8 →	-0.184	-0.071	<.001	<.001	3	8
UCEC	MCM4_T110 →	-1.002	-0.082	.003	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003096 vs ITGA1 — BRCA

Explore this scatter interactively →