Renal sodium ion transport

Across TCGA patient cohorts, RNA activity of the Renal sodium ion transport pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, LINC00265, and IL33, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion transport activity versus DUSP16 in COAD (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DUSP16 →	+0.409	+0.384	.003	.003	3	3
LSCC	LINC00265 →	+0.333	+0.297	<.001	.003	3	3
HNSC	IL33 →	-1.104	-0.209	.004	.001	3	3
HNSC	POTEF-AS1 →	+0.684	+0.155	.003	.001	3	3
BRCA	MAGED2 →	+0.866	+0.229	<.001	<.001	3	3
CCRCC	PGAP6 →	+0.315	+0.199	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003096 vs DUSP16 — COAD

Explore this scatter interactively →