Renal sodium ion transport

Across TCGA patient cohorts, RNA activity of the Renal sodium ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCEAL1, PHLDB2_S501, and STK39_S371, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal sodium ion transport activity versus TCEAL1 in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TCEAL1 →	+0.502	+0.332	<.001	.003	3	3
LSCC	PHLDB2_S501 →	-0.507	-0.277	<.001	<.001	3	3
CCRCC	STK39_S371 →	+1.188	+0.374	<.001	<.001	2	4
CCRCC	STK39_T354 →	+0.780	+0.210	<.001	<.001	3	3
GBM	LSM11_S15 →	+0.401	+0.278	<.001	<.001	3	3
UCEC	CEP152_S1247 →	-0.687	-0.352	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003096 vs TCEAL1 — UCEC

Explore this scatter interactively →