Regulation of glomerular filtration

Across TCGA cell cohorts, RNA activity of the Regulation of glomerular filtration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRO, EMP2, and CORO2B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRO grouped by Regulation of glomerular filtration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTPRO →	-0.364	-1.480	<.001	<.001	3	7
LUNG_NSCLC_LUAD	EMP2 →	-0.118	-0.948	.007	.001	3	7
URINARY_TRACT	CORO2B →	-0.367	-2.350	<.001	<.001	3	5
BLOOD_Myeloma	PPCDC →	-0.208	-1.558	.004	<.001	3	4
SOFT_TISSUE	OR5L2 →	-0.352	-1.465	.004	.002	3	4
LARGE_INTESTINE	VAPB →	-0.300	-1.451	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRO by Regulation of glomerular filtration activity — CNS

Explore this box plot interactively →