Renal water homeostasis

Across TCGA patient cohorts, RNA activity of the Renal water homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, RAD51AP1, and CD6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal water homeostasis activity versus SLC15A3 in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC15A3 →	+0.469	+0.226	.002	.004	3	4
OV	RAD51AP1 →	-0.975	-0.788	<.001	<.001	3	4
GBM	CD6 →	+0.491	+0.230	<.001	<.001	3	4
COAD	ATAD5 →	-0.502	-0.890	.001	<.001	3	4
LUAD	FBP1 →	+0.900	+0.204	<.001	.001	3	4
BRCA	RILP →	+0.530	+0.629	.007	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003091 vs SLC15A3 — LSCC

Explore this scatter interactively →