Renal water homeostasis

Across TCGA cell cohorts, RNA activity of the Renal water homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PKD2L2, GGPS1, and TRAF7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PKD2L2 grouped by Renal water homeostasis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PKD2L2 →	-0.109	-0.352	.006	.007	3	4
LUNG_NSCLC_LUAD	GGPS1 →	+0.747	+0.748	<.001	.002	3	4
PANCREAS	TRAF7 →	+0.655	+0.242	.003	.008	3	3
PANCREAS	KCTD1 →	+1.138	+0.383	<.001	<.001	3	3
PANCREAS	NUDT18 →	+0.740	+0.301	.002	.009	3	3
KIDNEY	DNAJA3 →	+0.868	+1.120	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PKD2L2 by Renal water homeostasis activity — PANCREAS

Explore this box plot interactively →