Renal water homeostasis

Across TCGA cell cohorts, RNA activity of the Renal water homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF9, CDKN1A, and NTSR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGEF9 grouped by Renal water homeostasis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ARHGEF9 →	-0.248	-0.076	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	CDKN1A →	-0.183	-0.101	.001	<.001	3	5
LARGE_INTESTINE	NTSR1 →	-0.140	-0.096	<.001	<.001	3	4
LARGE_INTESTINE	MOB1A →	-0.235	-0.142	<.001	.003	3	4
BONE	LCN6 →	-0.372	-0.129	.006	.005	3	4
LUNG_SCLC	ZNF669 →	+0.191	+0.128	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGEF9 by Renal water homeostasis activity — CNS

Explore this box plot interactively →