Renal water homeostasis

Across TCGA cell cohorts, RNA activity of the Renal water homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACP3, ZNF622, and MCTP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal water homeostasis activity versus ACP3 in SKIN (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACP3 →	-0.914	-0.210	.006	.001	3	5
BONE	ZNF622 →	+0.845	+0.357	<.001	.001	3	4
BONE	MCTP1 →	+3.022	+0.406	.006	.005	3	4
BREAST	BCCIP →	+0.723	+0.250	.009	.004	3	4
LUNG_NSCLC_LUAD	B9D2 →	+0.944	+0.203	<.001	.002	3	4
BLOOD_Leukemia	SPRED1 →	+1.428	+0.739	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003091 vs ACP3 — SKIN

Explore this scatter interactively →