Negative regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Negative regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TP53INP1, HCAR2, and SNTA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of systemic arterial blood pressure activity versus TP53INP1 in BRCA (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TP53INP1 →	+0.561	+0.250	.004	.005	3	4
OV	HCAR2 →	+0.620	+0.164	.002	.005	3	4
GBM	SNTA1 →	+0.668	+0.524	<.001	<.001	3	3
COAD	PEX11A →	+0.292	+0.289	.005	.005	3	3
COAD	FEZ2 →	+0.268	+0.346	.006	.008	3	3
COAD	RPL10P15 →	-0.475	-0.322	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003085 vs TP53INP1 — BRCA

Explore this scatter interactively →