Negative regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Negative regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC1A, DENND2B_S413, and TAF9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of systemic arterial blood pressure activity versus SMC1A in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC1A →	-0.218	-0.421	.001	.003	3	4
LSCC	DENND2B_S413 →	+0.906	+0.306	<.001	.001	3	4
PDAC	TAF9 →	-0.358	-0.462	<.001	<.001	3	3
OV	APC_S2449 →	+1.147	+0.303	<.001	<.001	3	3
PDAC	MYO9B_S1290 →	+0.661	+0.582	<.001	<.001	3	3
GBM	POLR2K →	-0.483	-0.765	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003085 vs SMC1A — GBM

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