Positive regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Positive regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf99, GJB4, and TCTN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of systemic arterial blood pressure activity versus C10orf99 in UCEC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C10orf99 →	+1.141	+0.763	.001	.001	3	3
UCEC	GJB4 →	+0.434	+0.700	.005	.008	3	3
PDAC	TCTN3 →	+0.208	+0.656	<.001	.001	3	3
CCRCC	NIPAL3 →	+0.385	+0.230	.009	.002	3	3
CCRCC	GAS6-DT →	-0.492	-0.239	.002	.006	3	3
COAD	EMP1 →	+0.551	+0.122	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003084 vs C10orf99 — UCEC

Explore this scatter interactively →