Positive regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Positive regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTBD2, TAF15, and KRT8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BTBD2 grouped by Positive regulation of systemic arterial blood pressure-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BTBD2 →	-0.988	-1.398	<.001	<.001	3	3
OVARY	TAF15 →	-0.867	-0.934	.005	.006	3	3
SOFT_TISSUE	KRT8 →	-4.987	-0.897	<.001	.001	3	3
LUNG_NSCLC_LUAD	ERAL1 →	-0.496	-0.737	.004	.001	3	3
SKIN	MSX2 →	-1.372	-0.851	.003	<.001	3	3
SKIN	PLAAT4 →	-1.586	-0.726	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BTBD2 by Positive regulation of systemic arterial blood pressure activity — OVARY

Explore this box plot interactively →