Regulation of systemic arterial blood pressure by renin-angiotensin

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by renin-angiotensin pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JAK1, CAVIN2_S364, and PPP1R12C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by renin-angiotensin activity versus JAK1 in UCEC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAK1 →	+0.273	+0.074	<.001	.001	3	8
BRCA	CAVIN2_S364 →	+0.655	+0.030	<.001	<.001	3	8
UCEC	PPP1R12C →	+0.397	+0.066	<.001	<.001	3	8
BRCA	SORBS1 →	+0.743	+0.060	<.001	<.001	3	8
LSCC	SEPTIN4_S117 →	+0.674	+0.056	<.001	<.001	3	7
BRCA	SHANK3 →	+0.322	+0.041	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003081 vs JAK1 — UCEC

Explore this scatter interactively →