Regulation of systemic arterial blood pressure by renin-angiotensin

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure by renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCT1, GYPC, and CD300LG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by renin-angiotensin activity versus MYCT1 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYCT1 →	+0.679	+0.180	<.001	<.001	3	6
OV	GYPC →	+0.632	+0.138	<.001	<.001	3	6
BRCA	CD300LG →	+0.972	+0.220	<.001	<.001	3	6
BRCA	ARHGEF15 →	+0.679	+0.163	<.001	<.001	3	6
BRCA	CTSG →	+1.059	+0.141	<.001	<.001	3	5
BRCA	MEOX2 →	+1.078	+0.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003081 vs MYCT1 — BRCA

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