Regulation of systemic arterial blood pressure by renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CANT1, STAT1, and SLC35B2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CANT1 grouped by Regulation of systemic arterial blood pressure by renin-angiotensin-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CANT1 →	-1.187	-1.436	.001	.008	3	6
BLOOD_Leukemia	STAT1 →	-0.870	-1.101	.008	<.001	3	5
STOMACH	SLC35B2 →	-0.516	-1.160	.003	.001	3	5
BREAST	MXRA8 →	-2.078	-0.881	<.001	<.001	3	4
BREAST	LENG8 →	-1.050	-0.758	.002	.003	3	4
BLOOD_Lymphoma	CRNKL1 →	-0.954	-1.783	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CANT1 by Regulation of systemic arterial blood pressure by renin-angiotensin activity — BLOOD_Lymphoma

Explore this box plot interactively →