Regulation of systemic arterial blood pressure by renin-angiotensin

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure by renin-angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC18B1, NSUN6, and FNDC3B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure by renin-angiotensin activity versus SLC18B1 in BLOOD_Leukemia (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC18B1 →	-1.239	-0.539	.001	.001	3	4
BLOOD_Leukemia	NSUN6 →	-0.648	-0.457	<.001	.007	3	4
BLOOD_Leukemia	FNDC3B →	+1.882	+0.702	<.001	.006	3	4
BLOOD_Leukemia	CTSZ →	+3.906	+0.901	<.001	.001	3	4
BLOOD_Leukemia	CNIH2 →	-0.629	-0.478	.001	.004	3	4
URINARY_TRACT	ARID3A →	+1.150	+0.285	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003081 vs SLC18B1 — BLOOD_Leukemia

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