Regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN2, CACNA1C, and RN7SKP275, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure activity versus CAVIN2 in BRCA (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAVIN2 →	+0.899	+0.196	<.001	<.001	3	6
BRCA	CACNA1C →	+0.781	+0.262	<.001	<.001	3	5
UCEC	RN7SKP275 →	+1.139	+0.562	.001	.005	3	4
BRCA	ZBTB16 →	+0.863	+0.204	.004	<.001	2	5
BRCA	PDE1A →	+0.850	+0.324	<.001	<.001	3	4
BRCA	DUSP1 →	+1.143	+0.229	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003073 vs CAVIN2 — BRCA

Explore this scatter interactively →