Regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FPR2, ZNF621, and NUP98, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FPR2 grouped by Regulation of systemic arterial blood pressure-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FPR2 →	-0.393	-0.168	.001	.003	3	6
LUNG_SCLC	ZNF621 →	+0.289	+0.205	.001	.001	3	6
LUNG_NSCLC_LUSC	NUP98 →	-0.396	-0.221	.001	.004	3	5
LUNG_NSCLC_LUAD	CHKB-CPT1B →	+0.076	+0.087	.003	<.001	3	5
BLOOD_Lymphoma	FBLN7 →	+0.449	+0.129	.008	.003	3	4
UPPER_AERODIGESTIVE_TRACT	DNAL1 →	-0.162	-0.142	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FPR2 by Regulation of systemic arterial blood pressure activity — LUNG_SCLC

Explore this box plot interactively →