Regulation of systemic arterial blood pressure

Across TCGA cell cohorts, RNA activity of the Regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX2, TIA1, and POGZ, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of systemic arterial blood pressure activity versus CBX2 in BONE (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CBX2 →	-1.913	-0.143	<.001	<.001	3	12
BONE	TIA1 →	-0.947	-0.198	.002	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	POGZ →	-1.070	-0.121	.001	.004	3	12
SOFT_TISSUE	UBN2 →	-0.678	-0.140	.002	.004	3	12
BONE	C21orf58 →	-1.502	-0.184	.003	.001	3	12
LUNG_NSCLC_LUAD	CHTOP →	-0.700	-0.115	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003073 vs CBX2 — BONE

Explore this scatter interactively →