Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

pathway activity — cross-omics
GO:0003072Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, TLN1, and P3H3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVCNRIP1 →-0.595-0.126.003.00136
COADTLN1 →-0.282-0.102<.001<.00136
COADP3H3 →-0.356-0.079.003<.00136
BRCACYRIA →-0.354-0.085.001.00335
COADMRPL54 →+0.304+0.070<.001<.00135
CCRCCABCB7 →+0.323+0.110.005.00635
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration