Renal system process involved in regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Renal system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT3_S299, RRP36_S73, and CHAF1B_S410, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system process involved in regulation of systemic arterial blood pressure activity versus CNOT3_S299 in COAD (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CNOT3_S299 →	-0.526	-0.039	<.001	.004	3	6
PDAC	RRP36_S73 →	-0.665	-0.045	<.001	<.001	3	6
COAD	CHAF1B_S410 →	-0.578	-0.036	<.001	.001	3	6
UCEC	CHEK2 →	-0.402	-0.048	.006	.003	3	6
LUAD	CLIC2 →	+0.400	+0.039	<.001	.002	3	6
OV	COIL_T303 →	-1.091	-0.049	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003071 vs CNOT3_S299 — COAD

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