Renal system process involved in regulation of systemic arterial blood pressure

Across TCGA patient cohorts, RNA activity of the Renal system process involved in regulation of systemic arterial blood pressure pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR2F1-AS1, SRPX, and DDX39A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system process involved in regulation of systemic arterial blood pressure activity versus NR2F1-AS1 in BRCA (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NR2F1-AS1 →	+0.529	+0.149	<.001	<.001	3	4
BRCA	SRPX →	+0.890	+0.111	.005	.008	3	4
CCRCC	DDX39A →	-0.216	-0.174	.001	.002	3	4
CCRCC	TXNL4A →	-0.181	-0.178	.001	<.001	3	4
CCRCC	PSMA4 →	-0.149	-0.132	.007	.002	3	4
BRCA	SHE →	+0.463	+0.111	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0003071 vs NR2F1-AS1 — BRCA

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